Together, histone acetyltransferases and histone deacetylases (HDACs) determine the
acetylation status of histones. This acetylation affects the regulation of gene expression, and …

Histone deacetylase (HDAC) inhibitors have been shown to be potent inducers of growth
arrest, differentiation, and/or apoptotic cell death of transformed cells in vitro and in vivo. One …

Histone deacetylase (HDAC) inhibitors (HDACi) cause cancer cell growth arrest and/or
apoptosis in vivo and in vitro. The HDACi suberoylanilide hydroxamic acid (SAHA) is in …

Histone deacetylases are key enzymes of epigenetic regulation and are therefore involved
in crucial cellular events like transcription, differentiation, apoptosis and cell division. The …

Histone deacetylase inhibitors (HDACi) developed as anti-cancer agents have a high
degree of selectivity for killing cancer cells. HDACi induce acetylation of histones and …

Suberoylanilide hydroxamic acid (SAHA) is the prototype of a family of hybrid polar
compounds that induce growth arrest in transformed cells and show promise for the …

Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a
potent inducer of phase 2 detoxification enzymes and inhibits tumorigenesis in animal …

Suberoylanilide hydroxamic acid (SAHA) is a potent inhibitor of histone deacetylases
(HDACs) that causes growth arrest, differentiation, and/or apoptosis of many tumor types in …

Acetylation of histones in chromatin is one mechanism involved in the regulation of gene
transcription and is tightly controlled by the balance of acetyltransferase and deacetylase …

The base sequence of DNA provides the genetic code for proteins. The regulation of
expression or suppression of gene transcription is largely determined by the structure of the …