The liver is the commonest site of metastatic disease for patients with colorectal cancer, with
at least 25% developing colorectal liver metastases (CRLM) during the course of their …

Fusobacterium nucleatum (Fn) is a dominant bacterial species in colorectal cancer (CRC)
tissue that is associated with cancer progression and poorer patient prognosis. Following a …

Neutrophils, the most abundant circulating leukocytes in human, play an indispensable role
in the innate immune response to microbial infections. However, the contribution of tumor …

Therapy resistance is the primary problem in treating late-stage colorectal cancer (CRC).
Claudins are frequently dysregulated in cancer, and several are being investigated as novel …

Cancer treatments have improved significantly during the last decade but are not yet
satisfactory. Combination therapy is often administered to improve efficacy and safety. Drug …

Camptothesome is a sphingomyelin-conjugated camptothecin (SM-CSS-CPT) nanovesicle
that fortified the therapeutic delivery of CPT in diverse cancer types. To mitigate the …

Background Early recurrence following liver resection for metastatic colorectal cancer
generally portends poor survival. We sought to identify factors associated with early disease …

FOLFOX (5-fluorouracil, leucovorin, oxaliplatin) chemotherapy is used to treat colorectal
cancer and can acutely induce metabolic dysfunction. However, the lasting effects on …

MicroRNAs (miRNAs), a class of small non-coding RNAs represent potential biomarkers for
colorectal cancer (CRC). The study hypothesized that miRNAs associated with liver …

Aims Clinical practice guidelines recommend palliative chemotherapy for most patients with
metastatic colorectal cancer. However, outcomes observed in the real world compared with …