The focus of this review is the human de novo purine biosynthetic pathway. The pathway
enzymes are enumerated, as well as the reactions they catalyze and their physical …

Purines are essential molecules that are components of vital biomolecules, such as nucleic
acids, coenzymes, signaling molecules, as well as energy transfer molecules. The de novo …

Purine-based molecules play ancient, fundamental, and evolutionarily-conserved roles
across life on Earth, ranging from DNA and RNA, to the universal energy currency, ATP. In …

N-terminal nucleophile (Ntn)-hydrolases catalyze the cleavage of amide bonds in a variety
of macromolecules, including the peptide bond in proteins, the amide bond in N-linked …

Acute myeloid leukemia (AML) is a devastating disease, and clinical outcomes are still far
from satisfactory. Here, to identify novel targets for AML therapy, we performed a genome …

Purine nucleotides play central roles in energy metabolism in the heart. Most fundamentally,
the free energy of hydrolysis of the adenine nucleotide adenosine triphosphate (ATP) …

Amino‐4‐imidazolecarboxamide‐ribosiduria (AICA)‐ribosiduria is an exceedingly rare
autosomal recessive condition resulting from the disruption of the bifunctional purine …

The proper regulation of nucleotide pools is essential for all types of cellular functions and
depends on de novo nucleotide biosynthesis, salvage, and degradation pathways. Despite …

In human cells, de novo purine nucleotide biosynthesis is known to be regulated through the
formation of a metabolon called purinosome. Here, we employed a bacterial two‐hybrid …

Engagement of neural stem/progenitor cells (NSPCs) into proper neuronal differentiation
requires the spatiotemporally regulated generation of metabolites. Purines are essential …