In general, heterocyclic compounds are a significant source of pharmacologically active
compounds. Among them, the indole scaffold widely distributes in natural products and …

Summary The Ca 2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) was touted as
a memory molecule, even before its involvement in long-term potentiation (LTP) was shown …

The indole scaffold is one of the most widespread heterocycles in the naturally occurring
and synthetic bioactive compounds including anticancer agents. Due to its biodiversity and …

Salivary gland cancer (SGC) is immensely heterogeneous, both in terms of its physical
manifestation and its aggressiveness. Developing a novel diagnostic and prognostic …

Eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) is a member of
a family of translation repressor proteins, and a well-known substrate of mechanistic target of …

In nature's collection of biologically active heterocycles, benzofuran derivatives constitute a
major group. The broad spectrum of pharmacological activity in individual benzofurans …

CK2 (casein kinase 2) is a serine/threonine protein kinase that is ubiquitous in eukaryotic
cells and plays important roles in a variety of cellular functions, including cell growth …

Triple-negative breast cancers (TNBCs) have poor prognosis and lack targeted therapies.
Here we identified increased copy number and expression of the PIM1 proto-oncogene in …

The ubiquitin system regulates essential cellular processes in eukaryotes. Ubiquitin is
ligated to substrate proteins as monomers or chains and the topology of ubiquitin …

mTOR is a central nutrient sensor that signals a cell to grow and proliferate. Through distinct
protein complexes it regulates different levels of available cellular energy substrates …