The brain has almost no energy reserve, but its activity coordinates organismal function, a
burden that requires precise coupling between neurotransmission and energy metabolism …

Lactate in the brain has long been associated with ischaemia; however, more recent
evidence shows that it can be found there under physiological conditions. In the brain …

Depression is a common mental illness, affecting more than 300 million people worldwide.
Decades of investigation have yielded symptomatic therapies for this disabling condition but …

Lactate has diverse roles in the brain at the molecular and behavioral levels under
physiological and pathophysiological conditions. This study investigates whether lysine …

Gastrointestinal and central function are intrinsically connected by the gut microbiota, an
ecosystem that has co-evolved with the host to expand its biotransformational capabilities …

Alterations in energy metabolism are associated with depression. However, the role of
glycolysis in the pathogenesis of depression and the underlying molecular mechanisms …

The gut microbiota is a complex and dynamic ecosystem essential for the proper functioning
of the organism, affecting the health and disease status of the individuals. There is …

It has been well established in epidemiological studies and randomized controlled trials that
habitual exercise is beneficial for brain health, such as cognition and mental health …

Overproduction of lactate (LA) can occur during exercise and in many diseases such as
cancers. Individuals with hyperlactatemia often display anemia, decreased serum iron, and …

Glucose is the mandatory fuel for the brain, yet the relative contribution of glucose and
lactate for neuronal energy metabolism is unclear. We found that increased lactate, but not …