Thirty per cent of all colorectal tumours develop in the rectum. The location of the rectum
within the bony pelvis and its proximity to vital structures presents significant therapeutic …

According to the main international clinical guidelines, the recommended treatment for
locally-advanced rectal cancer is neoadjuvant chemoradiotherapy followed by surgery …

Background Organ preservation after reaching clinical complete response on neoadjuvant
therapy is gaining interest for rectal cancers, although the role of radiation dose escalation is …

Background Watch and wait is a novel management strategy in patients with rectal cancer
who have a clinical complete response after neoadjuvant chemoradiotherapy. Surveillance …

Local recurrence after resection for rectal cancer remains common despite growing
acceptance that inadequate local excision may be implicated. In a prospective study of 190 …

Background In patients with rectal cancer who achieve clinical complete response after
neoadjuvant chemoradiotherapy, watch and wait is a novel management strategy with …

Background A uniform definition of a clinical near-complete response (near-CR) after
neoadjuvant (chemo) radiotherapy for rectal cancer is lacking. A clear definition is necessary …

Colorectal cancer is one of the commonest cancers worldwide. Radiotherapy has been
established as an indispensable component of treatment. Although conventional …

Purpose Organ preservation or nonoperative management of rectal cancer is of growing
interest. Image guided adaptive endorectal brachytherapy is a radiation dose escalation …

Inflammasomes are multiprotein intracellular complexes which are responsible for the
activation of inflammatory responses. Among various subtypes of inflammasomes, NLRP3 …