Cardiovascular disease risk modeling for astronauts: making the leap from Earth to space

JL Huff, I Plante, SR Blattnig, RB Norman… - Frontiers in …, 2022 - frontiersin.org
NASA has recently completed several long-duration missions to the International Space
Station and is solidifying plans to return to the Moon, with an eye toward Mars and beyond …

[HTML][HTML] Space radiation and cardiovascular disease risk

M Boerma, GA Nelson, V Sridharan… - World journal of …, 2015 - ncbi.nlm.nih.gov
Future long-distance space missions will be associated with significant exposures to
ionizing radiation, and the health risks of these radiation exposures during manned missions …

Metabolic phenotyping reveals a lipid mediator response to ionizing radiation

EC Laiakis, K Strassburg, R Bogumil… - Journal of proteome …, 2014 - ACS Publications
Exposure to ionizing radiation has dramatically increased in modern society, raising serious
health concerns. The molecular response to ionizing radiation, however, is still not …

Late onset cardiovascular dysfunction in adult mice resulting from galactic cosmic ray exposure

M Bishawi, FH Lee, DM Abraham, C Glass, SJ Blocker… - Iscience, 2022 - cell.com
The complex and inaccessible space radiation environment poses an unresolved risk to
astronaut cardiovascular health during long-term space exploration missions. To model this …

A priming dose of protons alters the early cardiac cellular and molecular response to 56Fe irradiation

SS Ramadan, V Sridharan, I Koturbash… - Life sciences in space …, 2016 - Elsevier
Purpose: Recent evidence suggests that the heart may be injured by ionizing radiation at
lower doses than was previously thought. This raises concerns about the cardiovascular …

LGM2605 reduces space radiation-induced NLRP3 inflammasome activation and damage in in vitro lung vascular networks

S Chatterjee, RA Pietrofesa, K Park, JQ Tao… - International journal of …, 2019 - mdpi.com
Updated measurements of charged particle fluxes during the transit from Earth to Mars as
well as on site measurements by Curiosity of Martian surface radiation fluxes identified …

Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model

AS Nemec-Bakk, V Sridharan, RD Landes… - Life sciences in space …, 2021 - Elsevier
Purpose: While there is concern about degenerative tissue effects of exposure to space
radiation during deep-space missions, there are no pharmacological countermeasures …

Cosmic Radiations and the Cardiovascular System: A Narrative Review

O Giacinto, F Pelliccia, A Minati… - Cardiology in …, 2024 - journals.lww.com
In recent times, space flights receive continued interest. Humankind's next two goals are to
return to the Moon and, a few years later, to land on the surface of Mars. Although …

Further Characterization of Multi-Organ DEARE and Protection by 16,16 Dimethyl Prostaglandin E2 in a Mouse Model of the Hematopoietic Acute Radiation …

T Wu, LM Pelus, PA Plett, CH Sampson… - Radiation …, 2023 - meridian.allenpress.com
Survivors of acute radiation exposure suffer from the delayed effects of acute radiation
exposure (DEARE), a chronic condition affecting multiple organs, including lung, kidney …

Dajana Parganlija1, 2*, Sebastian Gehlert2, 3, Frankyn Herrera1, Jörn Rittweger1, 4, Wilhelm Bloch2 and Jochen Zange1

NJ Szewczyk, J Pearson, D Parganlija… - … Health and Safety …, 2023 - books.google.com
One of the prevalent issues astronauts face during space flight is the redistribution of fluids
toward their upper body, a phenomenon that occurs due to the lack of gravity in space …