Circadian rhythms are endogenously generated rhythms with a period length of
approximately 24 hours. Evidence gathered during the past decade indicates that the …

▪ Abstract During the past four years, significant progress has been made in identifying the
molecular components of the mammalian circadian clock system. An autoregulatory …

Circadian rhythms influence most of our life activities, notably getting up and going to sleep
every day. The new edition of this book delves into the mechanisms surrounding how these …

Humans are diurnal organisms whose biological clock and temporal organization depend
on natural light/dark cycles. Throughout evolution, changes in the photoperiod were a signal …

This paper reviews abundant evidence suggesting that causes and course of aging and
cancers can be considered as being both light-and rhythm-related. We define …

We treated delayed sleep phase syndrome (DSPS) with an illuminated mask that provides
light through closed eyelids during sleep. Volunteers received either bright white light (2,700 …

Light is, clearly, a key to life on Earth and light, equally clearly, determines biological
rhythmicity in organisms. Light does the latter by setting internal or endogenous clocks …

In 2007, the IARC (WHO) has classified “shift-work that involves circadian disruption” as
potentially carcinogenic. Ample evidence leaves no doubt that shift-work is detrimental for …

The circadian timing system (CTS) has evolved in an environment where the rotation and
orbit of the earth and moon resulted in continuing cyclic variations of light and temperature …

Increasing evidence indicates that the circadian timing system is a fundamental homeostatic
system that potently influences human behavior and physiology throughout development …