Melatonin is an immune modulator that displays both pro‐and anti‐inflammatory properties.
Proinflammatory actions, which are well documented by many studies in isolated cells or …

Antioxidant enzymes form the first line of defense against free radicals in organisms. Their
regulation depends mainly on the oxidant status of the cell, given that oxidants are their …

Background Melatonin is widely available either on prescription for the treatment of sleep
disorders or as an over-the-counter dietary supplement. Melatonin has also recently been …

This review summarizes the numerous observations published in recent years which have
shown that one of the most significant of melatonin's pleiotropic effects is the regulation of …

A tight, physiological link between the pineal gland and the immune system is emerging
from a series of experimental studies. This link might reflect the evolutionary connection …

Recently, it was demonstrated that inbred strains of mice have a clearcut circadian rhythm of
pineal and serum melatonin. Moreover, it is known that melatonin is involved in many …

Melatonin is a natural compound synthesized by a variety of organs. It has been shown to
function as a cell-protective agent. Since 1994, when the first paper was published …

Aging is associated with a decline in immune function (immunosenescence), a situation
known to correlate with increased incidence of cancer, infectious and degenerative …

This book presents evidence that infection is cyclical with the seasons, and that this
phenomenon is mirrored in cycles of immune function. The book identifies the mechanisms …

Peroxynitrite is a toxic oxidant formed from the reaction of Superoxide and nitric oxide under
conditions of inflammation and oxidant stress. Here we demonstrate that the pineal …