Glutathione is a remarkably functional molecule with diverse features, which include being
an antioxidant, a regulator of DNA synthesis and repair, a protector of thiol groups in …

Currently, neuropathic pain is an underestimated socioeconomic health problem affecting
millions of people worldwide, which incidence may increase in the next years due to …

Transient receptor potential melastatin 2 (TRPM2) is a calcium (Ca 2+)-permeable non-
selective cation channel belonging to the TRP ion channel family. Oxidative stress-induced …

Sensory nerves are equipped with receptors and ion channels that allow them to detect and
respond to diverse chemical, mechanical, and thermal stimuli. These sensory proteins …

Parkinson's disease (PD) is one of most common neurodegenerative diseases.
Environmental stressors such as oxidative stress (OS), calcium ion influx, apoptosis, and …

Oxidative stress and apoptosis were induced in neuronal cultures by inhibition of glutathione
(GSH) biosynthesis with d, l-buthionine-S, R-sulfoximine (BSO). Transient receptor potential …

Photosensitization, an exaggerated sensitivity to harmless light, occurs genetically in rare
diseases, such as porphyrias, and in photodynamic therapy where short-term toxicity is …

Excessive Ca2+ influx and mitochondrial oxidative stress (OS) of trigeminal ganglia (TG)
have essential roles in the etiology of migraine headache and aura. The stimulation of …

The transient receptor potential melastatin (TRPM) protein family is an extensive group of
ion channels expressed in several types of mammalian cells. Many studies have shown that …

Ca 2+ is well known for its role as crucial second messenger in modulating many cellular
physiological functions, Ca 2+ overload is detrimental to cellular function and may present …