Glutamate is the most important excitatory neurotransmitter of the mammalian central
nervous system (CNS), playing an important role in memory, synaptic plasticity and neuronal …

Adult-onset neurodegenerative disorders are disabling and often fatal diseases of the
nervous system whose underlying mechanisms of cell death remain unknown. Defects in …

Aggregation of misfolded proteins and the associated loss of neurons are considered a
hallmark of numerous neurodegenerative diseases. Optineurin is present in protein …

GPCRs represent the largest family of integral membrane proteins and were first identified
as receptor proteins that couple via heterotrimeric G‐proteins to regulate a vast variety of …

Huntington's disease (HD) is a devastating autosomal dominant neurodegenerative disease
caused by a CAG trinucleotide repeat expansion encoding an abnormally long …

Macroautophagy/autophagy is a highly conserved process in eukaryotic cells. It plays a
critical role in cellular homeostasis by delivering cytoplasmic cargos to lysosomes for …

Myosins are a large family of actin-based cytoskeletal motors that use energy derived from
ATP hydrolysis to generate movement and force. Myosins of classes II, V and VI have …

The ubiquitin-proteasome system (UPS) and autophagy are the two major intracellular
protein quality control (PQC) pathways that are responsible for cellular proteostasis …

Introduction Prolactin is a peptide hormone mainly synthetized and secreted by the anterior
pituitary gland, but also by extrapituitary tissues, such as mammary gland, decidua, prostate …

OPTN (optineurin) is an autophagy receptor and mutations in the OPTN gene result in
familial glaucoma (E50K) and amyotrophic lateral sclerosis (ALS)(E478G). However, the …