Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort

RP Kommaddi, A Verma, G Muniz-Terrera… - Translational …, 2023 - nature.com
Women carry a higher burden of Alzheimer's disease (AD) compared to men, which is not
accounted entirely by differences in lifespan. To identify the mechanisms underlying this …

Association of biological sex with clinical outcomes and biomarkers of Alzheimer's disease in adults with Down syndrome

MF Iulita, A Bejanin, E Vilaplana… - Brain …, 2023 - academic.oup.com
The study of sex differences in Alzheimer's disease is increasingly recognized as a key
priority in research and clinical development. People with Down syndrome represent the …

Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease

PR Millar, BA Gordon, JK Wisch, SA Schultz… - Molecular …, 2023 - Springer
Background “Brain-predicted age” estimates biological age from complex, nonlinear
features in neuroimaging scans. The brain age gap (BAG) between predicted and …

Sex differences in blood biomarkers and cognitive performance in individuals with autosomal dominant Alzheimer's disease

C Vila‐Castelar, Y Chen, S Langella… - Alzheimer's & …, 2023 - Wiley Online Library
INTRODUCTION Plasma tau phosphorylated at threonine 217 (P‐tau217) and
neurofilament light (NfL) have emerged as markers of Alzheimer's disease (AD) pathology …

Sex differences in cognitive resilience in preclinical autosomal‐dominant Alzheimer's disease carriers and non‐carriers: baseline findings from the API ADAD …

C Vila‐Castelar, PN Tariot, KM Sink… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction Females may have greater susceptibility to Alzheimer's disease (AD)‐
pathology. We examined the effect of sex on pathology, neurodegeneration, and memory in …

Basal forebrain volume and metabolism in carriers of the Colombian mutation for autosomal dominant Alzheimer's disease

S Teipel, A Grazia, M Dyrba, MJ Grothe, N Pomara - Scientific reports, 2024 - nature.com
We aimed to study atrophy and glucose metabolism of the cholinergic basal forebrain in non-
demented mutation carriers for autosomal dominant Alzheimer's disease (ADAD). We …

Noncognitive species-typical and home-cage behavioral alterations in conditional presenilin 1/presenilin 2 double knockout mice

Y Si, C Guo, F Xiao, B Mei, B Meng - Behavioural Brain Research, 2022 - Elsevier
Impairments in activities of daily living (ADL) are common clinical symptoms of human
Alzheimer's disease (AD). Describing the ADL in AD animal models might provide more …

Molecular subgroup classification in alzheimer's disease by transcriptomic profiles

S Liu, Y Lu, D Geng - Journal of Molecular Neuroscience, 2022 - Springer
Alzheimer's disease (AD) is a progressive cognitive disorder that occurs worldwide, and the
lack of disease-modifying targets and pathways is a pressing issue. This study aimed to …

Investigation of sex differences in mutation carriers of the Dominantly Inherited Alzheimer Network

O Wagemann, Y Li, J Hassenstab… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Studies suggest distinct differences in the development, presentation,
progression, and response to treatment of Alzheimer's disease (AD) between females and …

Subjective cognitive decline and its relation to verbal memory and sex in cognitively unimpaired individuals from a Colombian cohort with autosomal-dominant …

JE Martinez, E Pardilla-Delgado… - Journal of the …, 2022 - cambridge.org
Objective: Subjective Cognitive Decline (SCD) may be an early indicator of risk for
Alzheimer's disease (AD). Findings regarding sex differences in SCD are inconsistent …