Glioblastoma (GBM) is the most deadly type of malignant brain tumor, despite extensive
molecular analyses of GBM cells. In recent years, the tumor microenvironment (TME) has …

Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

Glioblastoma (GBM) is a devastating type of brain tumor, and current therapeutic treatments,
including surgery, chemotherapy, and radiation, are palliative at best. The design of effective …

Altered cellular metabolism is a hallmark of gliomas. Propelled by a set of recent
technological advances, new insights into the molecular mechanisms underlying glioma …

Malignant stem cells have long been considered a key therapeutic target in leukemia.
Therapeutic strategies designed to target the fundamental biology of leukemia stem cells …

Background Metabolic plasticity has been increasingly thought to be a determinant of tumor
growth and metastasis. MACC1, a transcriptional regulator of MET, was recognized as an …

Although cancer is still one of the most significant global challenges facing public health, the
world still lacks complementary approaches that would significantly enhance the efficacy of …

Malignant cells support tumor proliferation and progression by adopting to metabolic
changes. Tumor cells altered metabolism by increasing glucose uptake and fermentation of …

Glioblastoma is the most malignant tumor occurring in the human central nervous system
with overall median survival time< 14.6 months. Current treatments such as chemotherapy …

Over the years, substantial evidence has definitively confirmed the existence of cancer stem-
like cells within tumors such as Glioblastoma (GBM). The importance of Glioblastoma stem …