Abstract Background Fibroblast growth factors (FGFs) and their receptors (FGFRs) play a
crucial role in cell fate and angiogenesis, with dysregulation of the signaling axis driving …

Urothelial bladder cancer (UC) is the most common malignancy involving the urinary system
and represents a significant health problem. Immunotherapy has been used for decades for …

Background FGFR3-altered urothelial cancer (UC) correlates with a non-T cell-inflamed
phenotype and has therefore been postulated to be less responsive to immune checkpoint …

Background Immune checkpoint blockade (ICB) therapy holds promise in metastatic
urothelial carcinoma (UC). Fibroblast growth factor receptor 3 (FGFR3) mutation drives T-cell …

The current personalized oncology era has witnessed significant efforts to integrate clinical,
pathological, and molecular classifications. The growing need for molecular biomarkers to …

Gene fusions result from either structural chromosomal rearrangement or aberrations
caused by splicing or transcriptional readthrough. The precise and distinctive presence of …

Simple Summary The aim of this study was to present and analyze the up-to-date literature
describing the epidemiology, genetics, and histopathology of bladder cancer, as well as the …

Background Selective tyrosine kinase inhibitors targeting fibroblast growth factor receptor
(FGFR) 1-4 genomic alterations are in development or have been approved for FGFR …

Background Muscle invasive urothelial bladder carcinoma (MIBC) present RB1 and TP53
somatic alterations in a variable percentage of tumors throughout all molecular subtypes …

Opinion statement As we come to better understand cancer genomics, we are increasingly
shifting towards precision medicine. FGFR has been elucidated as one of the oncogenic …