The mitogen-activated protein kinase (MAPK) p38/MAPK-activated protein kinase 2 (MK2)
signaling pathway plays an important role in the posttranscriptional regulation of tumor …

TLRs can activate two distinct branches of downstream signaling pathways. MyD88 and
Toll/IL-1R domain-containing adaptor inducing IFN-β (TRIF) pathways lead to the …

The human body has a remarkable ability to regulate inflammation, a biophysical response
triggered by virus infection and tissue damage. Sirt6 is critical for metabolism and lifespan; …

An inducible gene expression program is a hallmark of the host inflammatory response.
Recently, long intergenic non-coding RNAs (lincRNAs) have been shown to regulate the …

NO overproduction has been suggested to contribute to the immunopathology related to
malaria infection. Even though a role for some parasite molecules (eg, GPI) in NO induction …

During infection with the intracellular parasite Toxoplasma gondii, the presentation of
parasite-derived antigens to CD4+ and CD8+ T cells is essential for long-term resistance to …

Survival and growth of salmonellae within host cells are important aspects of bacterial
virulence. We have developed an assay to identify Salmonella typhimurium genes that are …

Myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM)
contribute to cancer-related inflammation and tumor progression. While several myeloid …

The Burkholderia cepacia complex (Bcc) is a group of opportunistic bacteria chronically
infecting the airways of patients with cystic fibrosis (CF). Several laboratories have shown …

The many virtues that made the yeast Saccharomyces cerevisiae a dominant model
organism for genetics and molecular biology, are now establishing its role in chemical …