The molecular heterogeneity of protein kinase C and its implications for cellular regulation

Y Nishizuka - Nature, 1988 - nature.com
Protein kinase C is now known to be a large family of proteins, with multiple subspecies that
have subtle individual enzymological characteristics. Some members of the family exhibit …

Peripheral nerve regeneration

C Ide - Neuroscience research, 1996 - Elsevier
Peripheral nerve regeneration comprises the formation of axonal sprouts, their outgrowth as
regenerating axons and the reinnervation of original targets. This review focuses on the …

The mechanism of protein kinase C activation

KP Huang - Trends in neurosciences, 1989 - Elsevier
Protein kinase C (PKC) consists of a family of closely related enzymes highly concentrated
in the CNS. These enzymes respond to the second messengers calcium (Ca 2+) and …

Impaired synapse elimination during cerebellar development in PKCγ mutant mice

M Kano, K Hashimoto, C Chen, A Abeliovich, A Aiba… - Cell, 1995 - cell.com
PKCy is highly expressed in Purkinje cells (PCs) but not in other types of neurons in the
cerebellum. The expression of PKCy changes markedly during cerebellar development …

Tissue and cellular distribution of the extended family of protein kinase C isoenzymes

WC Wetsel, WA Khan, I Merchenthaler… - The Journal of cell …, 1992 - rupress.org
Polyclonal isoenzyme-specific antisera were developed against four calcium-independent
protein kinase C (PKC) isoenzymes (delta, epsilon, epsilon', and zeta) as well as the calcium …

A long-term depression of AMPA currents in cultured cerebellar Purkinje neurons

DJ Linden, MH Dickinson, M Smeyne, JA Connor - Neuron, 1991 - cell.com
Cerebellar long-term depression (LTD) is a model of synaptic plasticity in which conjunctive
stimulation of parallel fiber and climbing fiber inputs to a Purkinje neuron induces a …

Cellular mechanisms of cerebellar LTD

H Daniel, C Levenes, F Crépel - Trends in neurosciences, 1998 - cell.com
In the past decade there have been advances in understanding the cellular mechanisms of
the long-term depression (LTD) of synaptic transmission at parallel fiber–Purkinje cell …

Phospholipase Cβ4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum

M Kano, K Hashimoto, M Watanabe… - Proceedings of the …, 1998 - National Acad Sciences
Elimination of excess climbing fiber (CF)–Purkinje cell synapses during cerebellar
development involves a signaling pathway that includes type 1 metabotropic glutamate …

The relationship of human papillomavirus-related cervical tumors to cigarette smoking, oral contraceptive use, and prior herpes simplex virus type 2 infection.

JR Daling, MM Madeleine, B McKnight, JJ Carter… - … , biomarkers & prevention …, 1996 - AACR
It has now been established that infection with human papillomavirus (HPV) is necessary for
the development of most cervical cancers. HPV is not sufficient for the development of …

Immunocytochemical localization of protein kinase C subspecies in the rat spinal cord: light and electron microscopic study

M Mori, A Kose, T Tsujino… - Journal of Comparative …, 1990 - Wiley Online Library
Distinct expression of protein kinase C (PKC) subspecies in the central nervous system
suggested that each subspecies has a distinct neural function in the processing and …