Mitochondria are the source of cellular energy production and are present in different types
of cells. However, their function is especially important for the heart due to the high demands …

Background: Cardiovascular diseases (CVDs) are a leading risk factor for mortality
worldwide and the number of CVDs victims is predicted to rise through 2030. While several …

Simvastatin reduces the blood concentration of cholesterol by inhibiting
hydroxymethylglutaryl-coenzyme A reductase, the rate-limiting enzyme in cholesterol …

To determine the effects of alpha lipoic acid (ALA) and vitamin E (Vit E) on mitochondrial
dysfunction caused by statins. A total of 38 Wistar Albino rats were used in this study. The …

A number of natural and chemical compounds that exert anti-oxidative properties are
demonstrated to be beneficial for brain and cognitive function, and some are reported to …

Inborn errors of metabolism (IEM) comprise a group of over 600 disorders, each with a
specific metabolic impairment due to a genetic defect. Urea cycle disorders (UCD) are IEM …

Some therapeutic and/or adverse effects of drugs may be related to their effects on
mitochondrial function. The effects of simvastatin, resveratrol, coenzyme Q10, acetylcysteine …

Statins, HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase inhibitors, have been
demonstrated to reduce all-cause mortality and the risk of major cardiovascular events …

Statins are the preferred therapy to treat hypercholesterolemia. Their main action consists of
inhibiting the cholesterol biosynthesis pathway. Previous studies report mitochondrial …

Urea cycle disorders (UCD) are inborn errors of metabolism that occur due to a loss of
function in enzymes and transporters involved in the urea cycle, causing an intoxication by …