Information processing imposes urgent metabolic demands on neurons, which have
negligible energy stores and restricted access to fuel. Here, we discuss metabolic …

Research to date has provided novel insights into lactate's positive role in multiple brain
functions and several brain diseases. Although notable controversies and discrepancies …

Lactate can be used by neurons as an energy substrate to support their activity. Evidence
suggests that lactate also acts on a metabotropic receptor called HCAR1, first described in …

High-caloric diet and physical inactivity predispose individuals to obesity and diabetes,
which are risk factors of hippocampal neurodegeneration and cognitive deficits. Along with …

Chronic pain is associated with long term plasticity of nociceptive pathways in the central
nervous system. Astrocytes can profoundly affect synaptic function and increasing evidence …

The endocannabinoid system (ECS) is involved in a variety of brain functions, mainly
through the activation of the type-1 cannabinoid receptors (CB1R). CB1R are highly …

More and more evidence shows how brain energy metabolism is the linkage between
physiological and morphological synaptic plasticity and memory consolidation. Different …

Astrocytes are key players in brain homeostasis and function. During the last years, several
studies have cemented this notion by showing that these cells respond to neuronal signals …

The development of brain in vitro models requires the application of novel biocompatible
materials and biopolymers as scaffolds for controllable and effective cell growth and …

Neurovascular abnormalities in mouse models of 16p11. 2 deletion autism syndrome are
reminiscent of alterations reported in murine models of glucose transporter deficiency …