The Hedgehog-GLI (HH-GLI) pathway is a highly conserved signaling that plays a critical
role in controlling cell specification, cell–cell interaction and tissue patterning during …

Abstract The Hedgehog (Hh) pathway has been implicated in a wide variety of human
tumors, and early clinical trials with pathway antagonists have validated Hh signaling as a …

Anaplastic lymphoma kinase was first described in 1994 as the NPM-ALK fusion protein that
is expressed in the majority of anaplastic large-cell lymphomas. ALK is a receptor protein …

RTKs (receptor tyrosine kinases) play important roles in cellular proliferation and
differentiation. In addition, RTKs reveal oncogenic potential when their kinase activities are …

Classical Hodgkin lymphoma (cHL) and anaplastic lymphoma kinase-positive, anaplastic
large cell lymphoma (ALK+ ALCL) are B and T cell lymphomas respectively, which express …

The Hedgehog (Hh) cascade controls cell proliferation, differentiation and patterning of
tissues during embryogenesis but is largely suppressed in the adult. The Hh pathway can …

Hedgehog signaling pathway is physiologically activated during embryogenesis, especially
in lung development. It is also reactivated in many solid tumors. In lung cancer, Hedgehog …

Paradigm shifting advances in cancer can occur after discovering the key oncogenic drivers
of the malignant process, understanding their detailed molecular mechanisms, and …

The Hedgehog pathway is a critical mediator of embryonic patterning and organ
development, including hematopoiesis. It influences stem cell fate, differentiation …

Successful treatment of diffuse large B-cell lymphoma (DLBCL) is frequently hindered by the
development of resistance to conventional chemotherapy resulting in disease relapse and …