DNA microarray technology: devices, systems, and applications

MJ Heller - Annual review of biomedical engineering, 2002 - annualreviews.org
▪ Abstract In this review, recent advances in DNA microarray technology and their
applications are examined. The many varieties of DNA microarray or DNA chip devices and …

MAPK, CREB and zif268 are all required for the consolidation of recognition memory

B Bozon, A Kelly, SA Josselyn… - … of the Royal …, 2003 - royalsocietypublishing.org
There has been nearly a century of interest in the idea that encoding and storage of
information in the brain requires changes in the efficacy of synaptic connections between …

Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment

EM Blalock, KC Chen, K Sharrow… - Journal of …, 2003 - Soc Neuroscience
Gene expression microarrays provide a powerful new tool for studying complex processes
such as brain aging. However, inferences from microarray data are often hindered by …

Neuronal activity rapidly induces transcription of the CREB‐regulated microRNA‐132, in vivo

AS Nudelman, DP DiRocco, TJ Lambert… - …, 2010 - Wiley Online Library
Activity‐dependent changes in gene‐expression are believed to underlie the molecular
representation of memory. In this study, we report that in vivo activation of neurons rapidly …

Memory-specific temporal profiles of gene expression in the hippocampus

S Cavallaro, V D'Agata, P Manickam… - Proceedings of the …, 2002 - National Acad Sciences
Many experiments in the past have demonstrated the requirement of de novo gene
expression during the long-term retention of learning and memory. Although previous …

Regulated transcription of the immediate‐early gene Zif268: Mechanisms and gene dosage‐dependent function in synaptic plasticity and memory formation

B Bozon, S Davis, S Laroche - Hippocampus, 2002 - Wiley Online Library
The immediate‐early gene Zif268 is a member of the Egr family of inducible transcription
factors. Data from gene expression studies have suggested that this gene may play a critical …

Posttranscriptional regulation of gene expression in learning by the neuronal ELAV-like mRNA-stabilizing proteins

A Quattrone, A Pascale, X Nogues… - Proceedings of the …, 2001 - National Acad Sciences
The view that memory is encoded by variations in the strength of synapses implies that long-
term biochemical changes take place within subcellular microdomains of neurons. These …

Altered expression of novel genes in the cerebral cortex following experimental brain injury

N Kobori, GL Clifton, PK Dash - Molecular brain research, 2002 - Elsevier
Damage to the cerebral cortex results in neurological impairments such as motor, attention,
memory and executive dysfunctions. To examine the molecular mechanisms contributing to …

Genetic approaches to molecular and cellular cognition: a focus on LTP and learning and memory

A Matynia, SA Kushner, AJ Silva - Annual Review of Genetics, 2002 - annualreviews.org
▪ Abstract Long-term potentiation (LTP) is the predominant experimental model for the
synaptic plasticity mechanisms thought to underlie learning and memory. This review is …

Genetic and histologic evidence implicates role of inflammation in traumatic brain injury-induced apoptosis in the rat cerebral cortex following moderate fluid …

H Shojo, Y Kaneko, T Mabuchi, K Kibayashi, N Adachi… - Neuroscience, 2010 - Elsevier
Traumatic brain injury (TBI) causes massive brain damage. However, the secondary injury
and temporal sequence of events with multiple mechanisms after the insult has not been …