The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …

The endocrine fibroblast growth factors (FGFs), FGF19, FGF21 and FGF23, are critical for
maintaining whole-body homeostasis, with roles in bile acid, glucose and lipid metabolism …

Circulating levels of fibroblast growth factor 23 (FGF23) are elevated in patients with chronic
kidney disease (CKD), but the mechanisms are poorly understood. Here we tested whether …

Patients with chronic kidney disease (CKD) develop increased levels of the phosphate-
regulating hormone, fibroblast growth factor (FGF) 23, that are associated with a higher risk …

Cardiovascular disease is the leading cause of death in patients with chronic kidney disease
(CKD). As CKD progresses, CKD-specific risk factors, such as disordered mineral …

Until recently, it was assumed that the only interaction between muscle and bone is
mechanical, that the muscle acts as a pulley and the bone as a lever to move the organism …

Fibroblast growth factor (FGF) 23 is a phosphaturic hormone whose physiologic actions on
target tissues are mediated by FGF receptors (FGFR) and klotho, which functions as a co …

Background—Patients with kidney disease have disordered bone and mineral metabolism,
including elevated serum concentrations of fibroblast growth factor-23 (FGF23). These …

The earliest mention of the term cardiorenal syndrome (CRS) came about from a 2004
National Heart, Lung, and Blood Institute Working Group conference evaluating the …

The term uraemic cardiomyopathy refers to the cardiac abnormalities that are seen in
patients with chronic kidney disease (CKD). Historically, this term was used to describe a …