Tumors consist of heterogeneous cell populations, and tumor heterogeneity plays key roles
in regulating tumorigenesis, metastasis, recurrence and resistance to anti-tumor therapies …

Mesenchymal stromal cells (MSCs) possess several fairly unique properties that, when
combined, make them ideally suited for cellular-based immunotherapy and as vehicles for …

Concepts and design of the project were done by SB, GM, SRC, KKP, JRC-G., and ABSB,
GM, SP, and CA performed the experiments. The analysis of the data was conducted by SB …

Bone marrow-derived human mesenchymal stem cells (hMSCs) are recruited to damaged or
inflamed tissues where they contribute to tissue repair. This multi-step process involves …

Pancreatic cancer is an aggressive malignancy with high mortality rates and poor
prognoses. Despite rapid progress in the diagnosis and treatment of pancreatic cancer, the …

The secretome produced by cells within the bone marrow is significant to homeostasis. The
bone marrow, a well-studied organ, has multiple niches with distinct roles for supporting …

Tumor dormancy, a state of tumor, is clinically undetectable and the outgrowth of dormant
tumor cells into overt metastases is responsible for cancer-associated deaths. However, the …

Pancreatic cancer, especially pancreatic ductal adenocarcinoma (PDAC), is one of the most
challenging clinical conditions due to its late-stage diagnosis and poor survival rates …

Pretreatment before transplantation initiates an inflammatory response. Inflammasomes are
key regulators of immune and inflammatory responses, but their role in regulating …

Cancer stem cells (CSCs) represent a subset of tumor cells that are responsible for
recurrence and metastasis of tumors. These cells are resistant to radiotherapy and …