Adhesion-type heterotrimeric guanine nucleotide–binding protein (G protein)–coupled
receptors (Adhesion-GPCRs) comprise a class of widely distributed seven-transmembrane …

The G protein-coupled receptor (GPCR) family comprises the largest class of cell surface
receptors found in metazoan proteomes. Within the novel GPCR subfamily of adhesion …

Translating a set of disease regions into insight about pathogenic mechanisms requires not
only the ability to identify the key disease genes within them, but also the biological …

PTEN is a tumor suppressor gene mutated in human cancers. Although many mutations
target the phosphatase domain, others create a truncated protein lacking the C-terminal PDZ …

PTEN/MMAC is a phosphatase that is mutated in multiple human tumors. PTEN/MMAC
dephosphorylates 3-phosphorylated phosphatidylinositol phosphates that activate …

Adhesion G protein-coupled receptors (aGPCRs)—one of the five main families in the GPCR
superfamily—have several atypical characteristics, including large, multi-domain N termini …

PDZ proteins, named for the common structural domain shared by the postsynaptic density
protein (PSD95), Drosophila disc large tumor suppressor (DlgA), and zonula occludens-1 …

MAGI-1 is a membrane-associated guanylate kinase protein at tight junctions in epithelial
cells. It interacts with various molecules and functions as a scaffold protein at cell junctions …

While a wide range of G protein‐coupled receptors (GPCR) have emerged as prime targets
for pharmacological intervention long ago, a distinct group of GPCR has only recently been …

A number of unusual seven-transmembrane molecules have recently been characterized
that have significant amino acid sequence similarity within the membrane-spanning …