Natural SIV hosts: showing AIDS the door

A Chahroudi, SE Bosinger, TH Vanderford, M Paiardini… - Science, 2012 - science.org
Many species of African nonhuman primates are naturally infected with simian
immunodeficiency viruses (SIVs) in the wild and in captivity. In contrast to HIV-infected …

The mucosal barrier and immune activation in HIV pathogenesis

JM Brenchley, DC Douek - Current Opinion in HIV and AIDS, 2008 - journals.lww.com
The mucosal barrier and immune activation in HIV pathogenesi... : Current Opinion in HIV and
AIDS The mucosal barrier and immune activation in HIV pathogenesis : Current Opinion in HIV …

[HTML][HTML] Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques

V Cecchinato, CJ Trindade, A Laurence, JM Heraud… - Mucosal …, 2008 - Elsevier
Loss of CD4+ T cells in the gut is necessary but not sufficient to cause AIDS in animal
models, raising the possibility that a differential loss of CD4+ T-cell subtypes may be …

Immune activation and AIDS pathogenesis

DL Sodora, G Silvestri - Aids, 2008 - journals.lww.com
The mechanisms by which HIV induces the immune dysfunction clinically defined as AIDS
have been a subject of intense study since the discovery of the virus in the early 1980s …

Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys

SN Gordon, NR Klatt, SE Bosinger… - The Journal of …, 2007 - journals.aai.org
HIV-infected humans and SIV-infected rhesus macaques experience a rapid and dramatic
loss of mucosal CD4+ T cells that is considered to be a key determinant of AIDS …

Understanding the benign nature of SIV infection in natural hosts

G Silvestri, M Paiardini, I Pandrea… - The Journal of …, 2007 - Am Soc Clin Investig
In striking contrast to HIV infection, natural SIV infection of African nonhuman primates is
asymptomatic and usually does not induce significant CD4+ T cell depletion despite high …

CCR5 as a coreceptor for human immunodeficiency virus and simian immunodeficiency viruses: a prototypic love-hate affair

AJ Jasinska, I Pandrea, C Apetrei - Frontiers in Immunology, 2022 - frontiersin.org
CCR5, a chemokine receptor central for orchestrating lymphocyte/cell migration to the sites
of inflammation and to the immunosurveillance, is involved in the pathogenesis of a wide …

Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts

DL Sodora, JS Allan, C Apetrei, JM Brenchley… - Nature medicine, 2009 - nature.com
The design of an effective AIDS vaccine has eluded the efforts of the scientific community to
the point that alternative approaches to classic vaccine formulations have to be considered …

Th17 cell dynamics in HIV infection

NR Klatt, JM Brenchley - Current Opinion in HIV and AIDS, 2010 - journals.lww.com
Th17 cell dynamics in HIV infection : Current Opinion in HIV and AIDS Th17 cell dynamics in
HIV infection : Current Opinion in HIV and AIDS Log in or Register Subscribe to journalSubscribe …

Into the wild: simian immunodeficiency virus (SIV) infection in natural hosts

I Pandrea, DL Sodora, G Silvestri, C Apetrei - Trends in immunology, 2008 - cell.com
Identifying distinctions between pathogenic HIV and simian immunodeficiency virus (SIV)
infections and nonprogressive SIV in natural African primate hosts might provide key …