Growing evidence indicates that oxidative and endoplasmic reticular stress, which trigger
changes in ion channels and inflammatory pathways that may undermine cellular …

Increasing evidence suggests that disorders of inflammation, oxidative stress, and
autophagy contribute to the pathogenesis of diabetic kidney disease (DKD). This study …

The present study investigated whether type 2 diabetes (T2D) is associated with
polymorphisms of genes encoding glutathione-metabolizing enzymes such as glutathione …

Background and aims Outcome trials using sodium glucose cotransporter type 2 inhibitors
have consistently shown their potential to preserve kidney function in diabetic and …

Abstract Rb1-inducible coiled-coil 1 (RB1CC1) has been demonstrated to function as an
inhibitor of proline-rich/Ca-activated tyrosine kinase 2 (PYK2) by binding to the kinase …

Diabetic kidney disease (DKD) is the leading cause of both chronic kidney disease (CKD)
and end-stage renal disease (ESRD). Previous studies showed that oxamate could regulate …

Introduction: Using a discovery/validation approach we investigated associations between a
panel of genes selected from a transcriptomic study and the estimated glomerular filtration …

Autophagy is a highly conserved pathway. Impairment of autophagy is implicated in the
pathogenesis of diabetic nephropathy. The current study applied a bioinformatics analysis to …

Diabetes is well-known disease for its complication and increasing population over time,
therefore new methods for complication assessment should be found. The aim of this study …