Nasopharyngeal carcinoma (NPC), also named the Cantonese cancer, is a unique cancer
with strong etiological association with infection of the Epstein-Barr virus (EBV). With …

Super-enhancers (SEs) in a broad range of human cell types are large clusters of enhancers
with aberrant high levels of transcription factor binding, which are central to drive expression …

As the most predominant RNA epigenetic regulation in eukaryotic cells, N6-
methyladenosine (m6A) plays a critical role in human tumorigenesis and cancer …

Epstein-Barr virus (EBV) is reportedly the first identified human tumor virus, and is closely
related to the occurrence and development of nasopharyngeal carcinoma (NPC), gastric …

Colorectal cancer is one of the most common cancers in the world. Although genomic
mutations and single nucleotide polymorphisms have been extensively studied, the …

Background & Aims We investigated the transcriptome of esophageal squamous cell
carcinoma (ESCC) cells, activity of gene regulatory (enhancer and promoter regions), and …

Squamous cell carcinomas (SCCs) are aggressive malignancies. Previous report
demonstrated that master transcription factors (TFs) TP63 and SOX2 exhibited overlapping …

Background & Aims Long non-coding RNAs (lncRNAs) are expressed in tissue-specific
pattern, but it is not clear how these are regulated. We aimed to identify squamous cell …

Recent studies suggest that targeting transcriptional machinery can lead to potent and
selective anticancer effects in cancers dependent on high and constant expression of certain …

Hepatocellular carcinoma (HCC) is one of the most dominant causes of neoplasm-related
deaths worldwide. In this study, we identify and characterize HCCL5, a novel cytoplasmic …