Over the past 15 years, rapid progress has been made in developmental therapeutics,
especially regarding the use of matched targeted therapies against specific oncogenic …

Background Liquid biopsy (LB) is a rapidly evolving diagnostic tool for precision oncology
that has recently found its way into routine practice as an adjunct to tissue biopsy (TB). The …

The clinical relevance of comprehensive molecular analysis in rare cancers is not
established. We analyzed the molecular profiles and clinical outcomes of 1,310 patients …

The mainstay of treatment for adult patients with gliomas, glioneuronal and neuronal tumors
consists of combinations of surgery, radiotherapy, and chemotherapy. For many systemic …

INFORM is a prospective, multinational registry gathering clinical and molecular data of
relapsed, progressive, or high-risk pediatric patients with cancer. This report describes long …

Next-generation sequencing (NGS) application in clinical practice requires the
implementation of molecular tumor boards (MTBs). Starting from a systematic review of …

The benefit of molecularly-informed therapies in cancer of unknown primary (CUP) is
unclear. Here, we use comprehensive molecular characterization by whole genome/exome …

Background Advanced cholangiocarcinoma has a poor prognosis. Molecular targeted
approaches have been proposed for patients after progression under first-line …

Background Germline variant evaluation in precision oncology opens new paths toward the
identification of patients with genetic tumor risk syndromes and the exploration of therapeutic …

Anatomic pathology has changed dramatically in recent years. Although the microscopic
assessment of tissues and cells is and will remain the mainstay of cancer diagnosis …