Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications

Z Li, Y Jiang, FP Guengerich, L Ma, S Li… - Journal of Biological …, 2020 - ASBMB
Cytochrome P450 enzymes (P450s) are broadly distributed among living organisms and
play crucial roles in natural product biosynthesis, degradation of xenobiotics, steroid …

Electrochemical transformations catalyzed by cytochrome P450s and peroxidases

N Kumar, J He, JF Rusling - Chemical Society Reviews, 2023 - pubs.rsc.org
Cytochrome P450s (Cyt P450s) and peroxidases are enzymes featuring iron heme cofactors
that have wide applicability as biocatalysts in chemical syntheses. Cyt P450s are a family of …

Biodegradation of levofloxacin by an acclimated freshwater microalga, Chlorella vulgaris

JQ Xiong, MB Kurade, BH Jeon - Chemical Engineering Journal, 2017 - Elsevier
The extensive contamination of levofloxacin (LEV) in aquatic ecosystems has attracted
increasing attention because of the potential for development of bacterial resistance and its …

Protein engineering for improving and diversifying natural product biosynthesis

C Li, R Zhang, J Wang, LM Wilson, Y Yan - Trends in biotechnology, 2020 - cell.com
Proteins found in nature have traditionally been the most frequently used biocatalysts to
produce numerous natural products ranging from commodity chemicals to pharmaceuticals …

Cytochrome P450 monooxygenases in biotechnology and synthetic biology

VB Urlacher, M Girhard - Trends in biotechnology, 2019 - cell.com
Cytochromes P450 (P450 or CYP) are heme-containing enzymes that catalyze the
introduction of one atom of molecular oxygen into nonactivated C–H bonds, often in a regio …

Synthetic biology of plant natural products: From pathway elucidation to engineered biosynthesis in plant cells

X Zhu, X Liu, T Liu, Y Wang, N Ahmed, Z Li… - Plant Communications, 2021 - cell.com
Plant natural products (PNPs) are the main sources of drugs, food additives, and new
biofuels and have become a hotspot in synthetic biology. In the past two decades, the …

Improved photosynthetic capacity and photosystem I oxidation via heterologous metabolism engineering in cyanobacteria

M Santos-Merino, A Torrado… - Proceedings of the …, 2021 - National Acad Sciences
Cyanobacteria must prevent imbalances between absorbed light energy (source) and the
metabolic capacity (sink) to utilize it to protect their photosynthetic apparatus against …

Ecotoxicological effects of sulfonamide on and its removal by the submerged plant Vallisneria natans (Lour.) Hara

L Zhu, H Xu, W Xiao, J Lu, D Lu, X Chen, X Zheng… - Water Research, 2020 - Elsevier
The extensive application of sulfonamides (SAs) raises concern regarding its negative
environmental effects. In aquatic environments, macrophytes may not only be affected by …

Light-driven biocatalytic oxidation

CH Yun, J Kim, F Hollmann, CB Park - Chemical Science, 2022 - pubs.rsc.org
Enzymes are the catalyst of choice for highly selective reactions, offering nature-inspired
approaches for sustainable chemical synthesis. Oxidative enzymes (eg, monooxygenases …

Rewiring photosynthetic electron transport chains for solar energy conversion

JM Lawrence, RM Egan, T Hoefer… - Nature Reviews …, 2023 - nature.com
Photosynthetic organisms have evolved versatile electron transport chains that efficiently
convert solar energy into chemical energy. Researchers can engineer these electron …