Clonal hematopoiesis results from enhanced fitness of a mutant hematopoietic stem and
progenitor cell (HSPC), but how such clones expand is unclear. We developed a technique …

RUNX1 is a critical transcription factor for the emergence of definitive hematopoiesis and the
precise regulation of adult hematopoiesis. Dysregulation of its regulatory network causes …

Systemic immune responses caused by chronic hypercholesterolaemia contribute to
atherosclerosis initiation, progression and complications. However, individuals often change …

Atherosclerosis is a major global health problem. Being a harbinger of a large number of
cardiovascular diseases, it ultimately leads to morbidity and mortality. At the same time …

Disease-initiating mutations in the transcription factor RUNX1 occur as germline and
somatic events that cause leukemias with particularly poor prognosis. However, the role of …

2, 2'4, 4'-tetrabromodiphenyl ether (PBDE-47) is one of the most widespread environmental
brominated flame-retardant congeners which has also been detected in animal and human …

Abstract ETS variant 6 (ETV6) encodes a transcriptional repressor expressed in
hematopoietic stem and progenitor cells (HSPCs), where it is required for adult …

Germ line mutations in the RUNX1 gene cause familial platelet disorder (FPD), an inherited
disease associated with lifetime risk to hematopoietic malignancies (HM). Patients with FPD …

Persistent pathogen infection is a known cause of malignancy, although with sparse
systematic evaluation across tumor types. We present a comprehensive landscape of 1060 …

Many inherited bone marrow failure syndromes (IBMFSs) present a high risk of
transformation to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) …