Vitamin D and the central nervous system: Causative and preventative mechanisms in brain disorders

X Cui, DW Eyles - Nutrients, 2022 - mdpi.com
Twenty of the last one hundred years of vitamin D research have involved investigations of
the brain as a target organ for this hormone. Our group was one of the first to investigate …

Antioxidant Functions of Vitamin D and CYP11A1-Derived Vitamin D, Tachysterol, and Lumisterol Metabolites: Mechanisms, Clinical Implications, and Future …

H Vázquez-Lorente, L Herrera-Quintana… - …, 2024 - pmc.ncbi.nlm.nih.gov
Evidence is increasing that vitamin D and CYP11A1-derived vitamin D, tachysterol, and
lumisterol metabolites play a significant antioxidant role beyond its classical functions in …

Antidiabetic drug sitagliptin blocks cyclophosphamide cerebral neurotoxicity by activating Nrf2 and suppressing redox cycle imbalance, inflammatory iNOS/NO/NF-κB …

AC Famurewa, NT Asogwa, SC Ezea - International Immunopharmacology, 2023 - Elsevier
Cyclophosphamide (CYP) is a classic DNA-interacting anticancer agent with broad
application in chemotherapy. However, CYP cerebral neurotoxicity is a worrisome side effect …

Tannic acid inhibits lipopolysaccharide-induced cognitive impairment in adult mice by targeting multiple pathological features

R Ullah, G Ali, A Baseer, SI Khan, M Akram… - International …, 2022 - Elsevier
Tannic acid (TA) is a natural compound present abundantly in fruit such as grapes and
green tea. In this study, we have evaluated the therapeutic efficacy of TA against …

Tremendous fidelity of vitamin D3 in age-related neurological disorders

M Skv, SM Abraham, O Eshwari, K Golla… - Molecular …, 2024 - Springer
Vitamin D3 (VD) is a secosteroid hormone and shows a pleiotropic effect in brain-related
disorders where it regulates redox imbalance, inflammation, apoptosis, energy production …

Minocycline alleviated scopolamine-induced amnesia by regulating antioxidant and cholinergic function

MHE Ghalibaf, A Rajabian, M Parviz, M Akbarian… - Heliyon, 2023 - cell.com
Background and aim Minocycline, a tetracycline derivative, has been found to exert
neuroprotective properties. The current project aimed to assess the antioxidant status and …

Anti-apoptotic and neurogenic properties in the hippocampus as possible mechanisms for learning and memory improving impacts of vitamin D in hypothyroid rats …

SH Rastegar-Moghaddam, F Alipour, M Hosseini… - Life Sciences, 2023 - Elsevier
The current study was designed to investigate the protective effects of Vitamin D (VD) on
hippocampal neurogenesis, apoptosis, and subsequent hippocampal-dependent learning …

[PDF][PDF] Molecular Regulation of the CNS by Vitamin D.

L Máčová, R Kancheva, M Bičíková - Physiological Research, 2023 - biomed.cas.cz
Vitamin D is a lipid-soluble vitamin that can be found in some foods. It is also produced
endogenously (in the presence of ultraviolet light), transported through the blood to the …

Resveratrol and 1, 25-dihydroxyvitamin D decrease Lingo-1 levels, and improve behavior in harmaline-induced Essential tremor, suggesting potential therapeutic …

Z Pirmoradi, M Nakhaie, H Ranjbar… - Scientific Reports, 2024 - nature.com
Essential tremor (ET) is a neurological disease that impairs motor and cognitive functioning.
A variant of the Lingo-1 genetic locus is associated with a heightened ET risk, and increased …

Docosahexaenoic Acid (DHA), Vitamin D3, and Probiotics Supplementation Improve Memory, Glial Reactivity, and Oxidative Stress Biomarkers in an Aluminum …

P Faccinetto-Beltrán, EE Reza-Zaldivar… - ACS …, 2024 - ACS Publications
Globally, the rise in neurodegenerative issues in tandem with shifts in lifestyle and aging
population has prompted a search for effective interventions. Nutraceutical compounds have …