Recent advances of self-assembling peptide-based hydrogels for biomedical applications

J Li, R Xing, S Bai, X Yan - Soft matter, 2019 - pubs.rsc.org
Peptide-based hydrogels have been proven to be preeminent biomedical materials due to
their high water content, tunable mechanical stability, great biocompatibility and excellent …

Synthetic nanoparticles for vaccines and immunotherapy

DJ Irvine, MC Hanson, K Rakhra, T Tokatlian - Chemical reviews, 2015 - ACS Publications
The immune system plays a critical role in our health. No other component of human
physiology plays a decisive role in as diverse an array of maladies, from deadly diseases …

Toward a better regeneration through implant‐mediated immunomodulation: harnessing the immune responses

B Zhang, Y Su, J Zhou, Y Zheng, D Zhu - Advanced science, 2021 - Wiley Online Library
Tissue repair/regeneration, after implantation or injury, involves comprehensive
physiological processes wherein immune responses play a crucial role to enable tissue …

Engineering synthetic vaccines using cues from natural immunity

DJ Irvine, MA Swartz, GL Szeto - Nature materials, 2013 - nature.com
Vaccines aim to protect against or treat diseases through manipulation of the immune
response, promoting either immunity or tolerance. In the former case, vaccines generate …

Effects of engineered nanoparticles on the innate immune system

Y Liu, J Hardie, X Zhang, VM Rotello - Seminars in immunology, 2017 - Elsevier
Engineered nanoparticles (NPs) have broad applications in industry and nanomedicine.
When NPs enter the body, interactions with the immune system are unavoidable. The innate …

Supramolecular biomaterials for cancer immunotherapy

H Liang, Q Lu, J Yang, G Yu - Research, 2023 - spj.science.org
Cancer immunotherapy has achieved tremendous successful clinical results and obtained
historic victories in tumor treatments. However, great limitations associated with feeble …

Immunological principles guiding the rational design of particles for vaccine delivery

KT Gause, AK Wheatley, J Cui, Y Yan, SJ Kent… - ACS …, 2017 - ACS Publications
Despite the immense public health successes of immunization over the past century,
effective vaccines are still lacking for globally important pathogens such as human …

Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype

SL Demento, W Cui, JM Criscione, E Stern, J Tulipan… - Biomaterials, 2012 - Elsevier
Particulate vaccines are emerging promising technologies for the creation of tunable
prophylactics against a wide variety of conditions. Vesicular and solid biodegradable …

Interactions between nanoparticles and dendritic cells: from the perspective of cancer immunotherapy

J Jia, Y Zhang, Y Xin, C Jiang, B Yan, S Zhai - Frontiers in oncology, 2018 - frontiersin.org
Dendritic cells (DCs) are the primary antigen-presenting cells and play key roles in the
orchestration of the innate and adaptive immune system. Targeting DCs by nanotechnology …

TLR4-based immunotherapeutics in cancer: a review of the achievements and shortcomings

MA Shetab Boushehri, A Lamprecht - Molecular pharmaceutics, 2018 - ACS Publications
Toll-like Receptor 4 (TLR4) agonists have had a long journey in the field of cancer
immunotherapy. Nevertheless, despite the remarkable number of the TLR4 ligands that …