On the stage of bacterial signal transduction and regulation, bis-(3′-5′)-cyclic dimeric
guanosine monophosphate (c-di-GMP) has long played the part of Sleeping Beauty. c-di …

Abstract Bis-(3′-5′)-cyclic dimeric GMP (c-di-GMP) is a ubiquitous second messenger that
regulates cell surface-associated traits in bacteria. Components of this regulatory network …

Elevated levels of the second messenger cyclic dimeric GMP, c‐di‐GMP, promote transition
of bacteria from single motile cells to surface‐attached multicellular communities. Here we …

In all domains of life nucleotide-based second messengers transduce signals originating
from changes in the environment or in intracellular conditions into appropriate cellular …

Cyclic di-guanosine monophosphate (c-di-GMP) represents an important ubiquitous second
messenger in bacteria. It controls the transition between a sessile and a motile lifestyle of …

Cyclic-di-GMP is a bacterial second messenger that controls the switch between motile and
sessile states. It is synthesized by proteins containing the enzymatic GGDEF domain and …

Quorum sensing (QS) has attracted great attention due to its important role in the bacterial
interactions and its relevance to water management. With the development of high …

Most bacteria can exist in either a planktonic-motile single-cell state or an adhesive
multicellular state known as a biofilm. Biofilms cause medical problems and technical …

Abstract c-di-GMP riboswitches are structured RNAs located in the 5′-untranslated regions
(5′-UTRs) of mRNAs that regulate expression of downstream genes in response to …

Clostridium difficile infections have become a major healthcare concern in the last decade
during which the emergence of new strains has underscored this bacterium's capacity to …