Alteration in the density and composition of extracellular matrix (ECM) occurs in tumors. The
alterations toward both stiffness and degradation are contributed to tumor growth and …

The extracellular matrix (ECM) is an integral component of all organs and plays a pivotal
role in tissue homeostasis and repair. While the ECM was long thought to mostly have …

Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the
development of the alveoli, heart, and lymphatic vascular system. Emerging evidence …

Podoplanin (PDPN) is a cell-surface mucin-like glycoprotein that plays a critical role in tumor
development and normal development of the lung, kidney, and lymphatic vascular systems …

Lipid rafts are tightly packed, cholesterol-and sphingolipid-enriched microdomains within the
plasma membrane that play important roles in many pathophysiologic processes. Rafts have …

The main cause of cancer-related mortality, metastasis, is a complex, multi-step process.
The extracellular matrix (ECM) component of solid tumors has been implicated in metastatic …

Invadopodia and podosomes are discrete, actin‐based molecular protrusions that form in
cancer cells and normal cells, respectively, in response to diverse signaling pathways and …

Cancer cells are subjected to fluid shear stress during passage through the venous and
lymphatic system. Caveolin-1 (Cav-1), a principal structural component of caveolar …

Ovarian carcinomatosis is characterized by the accumulation of carcinoma‐associated
mesothelial cells (CAMs) in the peritoneal stroma and mainly originates through a …

Astrocytes respond to injury, infection, and inflammation in the central nervous system by
acquiring reactive states in which they may become dysfunctional and contribute to disease …