Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays
pivotal roles in the immune response. Discovered as a T cell growth factor, IL-2 additionally …

Recent findings in epigenetics shed new light on the regulation of gene expression in the
central nervous system (CNS) during stress. The most frequently studied epigenetic …

The cell is a multi-scale structure with modular organization across at least four orders of
magnitude. Two central approaches for mapping this structure—protein fluorescent imaging …

Satb2 is a DNA-binding protein that regulates chromatin organization and gene expression.
In the developing brain, Satb2 is expressed in cortical neurons that extend axons across the …

SATB1 (special AT-rich sequence binding protein 1) organizes cell type–specific nuclear
architecture by anchoring specialized DNA sequences and recruiting chromatin remodeling …

Keratinocyte differentiation is an essential process for epidermal stratification and stratum
corneum formation. Keratinocytes proliferate in the basal layer of the epidermis and start …

The interleukin 23 (IL-23) is a key pro-inflammatory cytokine in the development of chronic
inflammatory diseases, such as psoriasis, inflammatory bowel diseases, multiple sclerosis …

The aging process starts directly after birth and lasts for the entire lifespan; it manifests itself
with a decline in an organism's ability to adapt and is linked to the development of age …

The function of the subnuclear structure the promyelocytic leukaemia (PML) body is unclear
largely because of the functional heterogeneity of its constituents. Here, we provide the …

Mechanisms of tissue-specific gene expression regulation via 3D genome organization are
poorly understood. Here we uncover the regulatory chromatin network of developing T cells …