Sharp wave ripples (SPW‐Rs) represent the most synchronous population pattern in the
mammalian brain. Their excitatory output affects a wide area of the cortex and several …

The kainic acid model of temporal lobe epilepsy has greatly contributed to the
understanding of the molecular, cellular and pharmacological mechanisms underlying …

Epileptogenesis is a chronic process that can be triggered by genetic or acquired factors,
and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a …

Experimental models of epilepsy are useful to identify potential mechanisms of
epileptogenesis, seizure genesis, comorbidities, and treatment efficacy. The kainic acid (KA) …

In order to understand the pathophysiology of temporal lobe epilepsy (TLE), and thus to
develop new pharmacological treatments, in vivo animal models that present features …

Diverse brain insults, including traumatic brain injury, stroke, infections, tumors,
neurodegenerative diseases, and prolonged acute symptomatic seizures, such as complex …

This article describes current experimental models of status epilepticus (SE) and neuronal
injury for use in the screening of new therapeutic agents. Epilepsy is a common neurological …

High frequency oscillations (HFO) have a variety of characteristics: band-limited or broad-
band, transient burst-like phenomenon or steady-state. HFOs may be encountered under …

We reviewed computer models that have been developed to reproduce and explain
epileptiform activity. Unlike other already-published reviews on computer models of …

In patients being evaluated for epilepsy and in animal models of epilepsy,
electrophysiological recordings are carried to capture seizures to determine the existence of …