EPA and DHA in microalgae: Health benefits, biosynthesis, and metabolic engineering advances

M Jesionowska, J Ovadia… - Journal of the …, 2023 - Wiley Online Library
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are ω‐3 very long‐chain
polyunsaturated fatty acids (VLC‐PUFAs) that offer a wide range of human health benefits …

Natural and recombinant bioactive compounds from Schizochytrium sp.: Recent advances and future prospects

P Castro-Cosio, E Monreal-Escalante… - Algal Research, 2023 - Elsevier
Schizochytrium sp. is a unicellular heterotrophic marine protist, with global distribution used
at an industrial scale for saturated fatty acid and polyunsaturated fatty acid production …

bZIP transcription factor FabR: Redox-dependent mechanism controlling docosahexaenoic acid biosynthesis and H2O2 stress response in Schizochytrium sp.

Y Liu, X Han, Y Dai, Z Chen - Free Radical Biology and Medicine, 2024 - Elsevier
Schizochytrium sp. is an important industrial strain for commercial production of
docosahexaenoic acid (DHA), which plays essential physiological roles in infant …

Overexpression of SR enhances the accumulation of biomass, fatty acids, and β-carotene in Schizochytrium

K Lu, F Wang, L Chen, W Zhang - Bioresource Technology, 2023 - Elsevier
Strategies for enhancing biomass accumulation and increasing the production of fatty acids
and β-carotene in Schizochytrium are hindered by the lack of suitable targets. In this study …

Enhancement of lipid accumulation and docosahexaenoic acid synthesis in Schizochytrium sp. H016 by exogenous supplementation of sesamol

Z Bao, Y Zhu, Y Feng, K Zhang, M Zhang, Z Wang… - Bioresource …, 2022 - Elsevier
Schizochytrium sp. is one of the most promising marine oleaginous microorganisms for
industrial production of docosahexaenoic acid (DHA). In this study, the exogenous …

Enhancing the accumulation of lipid and docosahexaenoic acid in Schizochytrium sp. by co‐overexpression of phosphopantetheinyl transferase and ω‐3 fatty acid …

J Li, Y Zheng, WQ Yang, ZY Wei, YS Xu… - Biotechnology …, 2023 - Wiley Online Library
Docosahexaenoic acid (DHA) as one of ω‐3 polyunsaturated fatty acids (PUFAs), plays a
key role in brain development, and is widely used in food additives and the pharmaceutical …

Metabolic engineering of Schizochytrium sp. for superior docosahexaenoic acid production

X Han, Y Liu, Y Yuan, Z Chen - Algal Research, 2024 - Elsevier
Schizochytrium sp. is an industrial producer of docosahexaenoic acid (DHA), which is an
important omega-3 polyunsaturated fatty acid used in the nutraceutical and food industry …

Modulating DHA-Producing Schizochytrium sp. toward Astaxanthin Biosynthesis via a Seamless Genome Editing System

PY Liu, G Li, CB Lin, JJ Wu, S Jiang… - ACS Synthetic …, 2022 - ACS Publications
Schizochytrium sp. is commercially used for the production of docosahexaenoic acid (DHA).
Some strains of Schizochytrium sp. are also known to produce low amounts of carotenoids …

Zinc Finger Protein LipR Represses Docosahexaenoic Acid and Lipid Biosynthesis in Schizochytrium sp.

X Han, Y Liu, Z Chen - Applied and Environmental Microbiology, 2022 - Am Soc Microbiol
The heterotrophic marine microalgae Schizochytrium sp. is an important industrial producer
of docosahexaenoic acid (DHA). Increased production of DHA and lipids in Schizochytrium …

High‐copy genome integration and stable production of p‐coumaric acid via a POT1‐mediated strategy in Saccharomyces cerevisiae

H Qi, Y Li, M Cai, J He, J Liu, X Song… - Journal of Applied …, 2022 - academic.oup.com
Aims To overcome the defective unstable production of p‐coumaric acid (p‐CA) using
episomal plasmids and simultaneously achieve genetic stability and high‐copy integration …