By 2050, the aging population is predicted to expand by over 100%. Considering this rapid
growth, and the additional strain it will place on healthcare resources because of age …

Aging is a complex biological process that increases the risk of age-related cognitive
degenerative diseases such as dementia, including Alzheimer's disease (AD), Lewy Body …

Trained immunity enhances the responsiveness of immune cells to subsequent infections or
vaccinations. Here we demonstrate that pre-vaccination with bacteria-derived outer …

Selective neurodegeneration is a critical causal factor in Alzheimer's disease (AD); however,
the mechanisms that lead some neurons to perish, whereas others remain resilient, are …

Astrocytes are essential in maintaining normal brain functions such as blood brain barrier
(BBB) homeostasis and synapse formation as the most abundant cell type in the central …

Background The necessity of including both males and females in molecular neuroscience
research is now well understood. However, there is relatively limited basic biological data on …

Complex biological processes, such as organogenesis and homeostasis, are stringently
regulated by genetic programs that are fine-tuned by epigenetic factors to establish cell fates …

Sex differences in the incidence, clinical manifestation, disease course, and prognosis of
neurological diseases, such as autism spectrum disorders or Alzheimer's disease, have …

Gene expression in the aging brain depends on transcription signals generated by
senescent physiology, interacting with genetic and epigenetic programs. In turn …

Sexual dimorphisms exist in multiple domains, from learning and memory to neurocognitive
disease, and even in the immune system. Male sex has been associated with increased …