Psychosis superspectrum I: Nosology, etiology, and lifespan development
This review describes the Hierarchical Taxonomy of Psychopathology (HiTOP) model of
psychosis-related psychopathology, the psychosis superspectrum. The HiTOP psychosis …
psychosis-related psychopathology, the psychosis superspectrum. The HiTOP psychosis …
The use of polygenic risk scores to identify phenotypes associated with genetic risk of schizophrenia: Systematic review
Studying the phenotypic manifestations of increased genetic liability for schizophrenia can
increase our understanding of this disorder. Specifically, information from alleles identified in …
increase our understanding of this disorder. Specifically, information from alleles identified in …
Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence
Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders associated with
cognitive impairment, which is considered a major determinant of functional outcome …
cognitive impairment, which is considered a major determinant of functional outcome …
A concerted neuron–astrocyte program declines in ageing and schizophrenia
E Ling, J Nemesh, M Goldman, N Kamitaki, N Reed… - Nature, 2024 - nature.com
Human brains vary across people and over time; such variation is not yet understood in
cellular terms. Here we describe a relationship between people's cortical neurons and …
cellular terms. Here we describe a relationship between people's cortical neurons and …
Polygenic risk scores in clinical psychology: bridging genomic risk to individual differences
R Bogdan, DAA Baranger… - Annual review of clinical …, 2018 - annualreviews.org
Genomewide association studies (GWASs) across psychiatric phenotypes have shown that
common genetic variants generally confer risk with small effect sizes (odds ratio< 1.1) that …
common genetic variants generally confer risk with small effect sizes (odds ratio< 1.1) that …
Identification of genetic loci jointly influencing schizophrenia risk and the cognitive traits of verbal-numerical reasoning, reaction time, and general cognitive function
Importance Schizophrenia is associated with widespread cognitive impairments. Although
cognitive deficits are one of the factors most strongly associated with functional outcome in …
cognitive deficits are one of the factors most strongly associated with functional outcome in …
Heritability of neuropsychological measures in schizophrenia and nonpsychiatric populations: a systematic review and meta-analysis
GAM Blokland, RI Mesholam-Gately… - Schizophrenia …, 2017 - academic.oup.com
Schizophrenia is characterized by neuropsychological deficits across many cognitive
domains. Cognitive phenotypes with high heritability and genetic overlap with schizophrenia …
domains. Cognitive phenotypes with high heritability and genetic overlap with schizophrenia …
Polygenic risk score increases schizophrenia liability through cognition-relevant pathways
Cognitive deficit is thought to represent, at least in part, genetic mechanisms of risk for
schizophrenia, with recent evidence from statistical modelling of twin data suggesting direct …
schizophrenia, with recent evidence from statistical modelling of twin data suggesting direct …
Genetic overlap between general cognitive function and schizophrenia: a review of cognitive GWASs
General cognitive (intelligence) function is substantially heritable, and is a major
determinant of economic and health-related life outcomes. Cognitive impairments and …
determinant of economic and health-related life outcomes. Cognitive impairments and …
Polygenic risk scores shed light on the relationship between schizophrenia and cognitive functioning: review and meta-analysis
Schizophrenia is a multifactorial disease associated with widespread cognitive impairment.
Although cognitive deficits are one of the factors most strongly associated with functional …
Although cognitive deficits are one of the factors most strongly associated with functional …