The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene
expression, and DNA methylation abnormalities are often observed in diseases. The ten …

Acute myeloid leukemia (AML) with t (8; 21)(q22; q22. 1); RUNX1-RUNX1T1, one of the core-
binding factor leukemias, is one of the most common subtypes of AML with recurrent genetic …

TET2 is recurrently mutated in acute myeloid leukemia (AML) and its deficiency promotes
leukemogenesis (driven by aggressive oncogenic mutations) and enhances leukemia stem …

The ten-eleven translocation (TET) family of enzymes were originally cloned from the
translocation breakpoint of t (10; 11) in infant acute myeloid leukemia (AML) with …

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease that
has a poor prognosis. Recent advances in genomics and molecular biology have led to a …

Aging is associated with significant changes in the hematopoietic system, including
increased inflammation, impaired hematopoietic stem cell (HSC) function, and increased …

Regulation of genome‐wide DNA methylation is fundamental for a variety of biological
processes such as mammalian development, stem cell function, cellular proliferation …

Myeloid malignancies are clonal hematopoietic disorders that are comprised of a spectrum
of genetically heterogeneous disorders, including myelodysplastic syndromes (MDS) …

Additional sex combs-like (ASXL) proteins are mammalian homologues of additional sex
combs (Asx), a regulator of trithorax and polycomb function in Drosophila. While there has …

AML1-ETO leukemia is the most common cytogenetic subtype of acute myeloid leukemia,
defined by the presence of t (8; 21). Remarkable progress has been achieved in …