Many polyketide-derived natural products contain a syn-or anti-1, 3-diol unit. No general and
simple approach exists for the flexible synthesis of polyols and other polyketide-derived …

The large volume of research studying hydrogenation catalysis might suggest that
stereoselective hydrogenation of alkenes is a solved problem, but we believe the most …

An asymmetric Ni-catalyzed reductive cross-coupling has been developed to prepare
enantioenriched allylic silanes. This enantioselective reductive alkenylation proceeds under …

The enantioselective crotylation of aldehydes with 1, 2-diaminochlorocrotylsilane reagents is
effectively catalyzed by Sc (OTf) 3. The one significant limitation on the utility of these …

A copper/N-heterocyclic carbene-catalyzed asymmetric allylic substitution of allyl
phosphates with a silylboronate has been developed to give highly enantioenriched …

Covering: 1993 to 2007 Initially isolated in trace quantities from deep-sea sponges, the
structurally related polyketides discodermolide and dictyostatin share the same microtubule …

Three subjects concerning novel reactions involving π-allylpalladium and π-allylnickel as
intermediates are reviewed: the first is the umpolung of π-allylpalladium, an alternation of …

The contribution of chiral sulfoxides as versatile auxiliaries in the field of organic chemistry
has shown a prevalent interest in the asymmetric synthesis of natural products during the …

An efficient, highly convergent stereocontrolled synthesis of (+)-discodermolide has been
achieved with 2.1% overall yield (27 steps longest linear sequence). The absolute …

A highly convergent asymmetric synthesis of the actin-depolymerizing agent (−)-mycalolide
A has been achieved through the assembly and union of the C1− C19 trisoxazole fragment …