Tau phosphorylation is regulated by a balance between tau kinase and phosphatase
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …

Protein kinases (PKs) have emerged as one of the most intensively investigated drug targets
in current pharmacological research, with indications ranging from oncology to …

Human chronic myelogenous leukaemia is characterized by a reciprocal translocation
between chromosomes 9 and 22 resulting in an abbreviated form of chromosome 22 and …

We have identified and molecularly cloned 46 kb of human DNA from chromosome 22 using
a probe specific for the Philadelphia(Ph') translocation breakpoint domain of one chronic …

The transforming genes of oncogenic retroviruses are homologous to a group of
evolutionary conserved cellular onc genes1. The human cellular homologue (c-abl) of the …

In the central nervous system (CNS), the principal mediators of fast synaptic excitatory
neurotransmission are L-glutamate-gated ion channels that are responsive to the glutamate …

Chronic myeloid leukaemia (CML) was the first neoplastic disease for which knowledge of
the genotype led to a rationally designed therapy. As a result of its well known …

The localization of cellular oncogenes near the break points of tumour-specific chromosomal
aberrations suggests an involvement of these genes in the generation of neoplasms1, 2 …

The human c-abl oncogene maps within the region (q34-qter) of chromosome 9 which is
translocated to chromosome 22, the Philadelphia (Ph′) chromosome, in chronic myelocytic …

Vertebrate genomes contain proto-oncogenes whose enhanced expression or alteration by
mutation seems to be involved in the development of naturally occurring tumours1, 2. These …