Over the past decade, covalent kinase inhibitors (CKI) have seen a resurgence in drug
discovery. Covalency affords a unique set of advantages as well as challenges relative to …

Turmeric (Curcuma longa) is a popular Indian spice that has been used for centuries in
herbal medicines for the treatment of a variety of ailments such as rheumatism, diabetic …

The selenoprotein thioredoxin reductases (TrxRs) have been extensively studied as a
potential target for the development of anticancer drugs. Herein, we designed, synthesized …

ABSTRACT Introduction: Curcumin (Diferuloylmethane) is a natural phenolic compound,
which belongs to the curcuminoid family, presenting pleiotropic activity and low …

Murugesan K, Koroth J, Srinivasan PP, et al. Int J Nanomedicine. 2019; 14: 5257–5270. The
Editor and Publisher of International Journal of Nanomedicine wish to retract the published …

Tuberculosis (TB) is a major public health concern worldwide with over 2 billion people
currently infected. The rise of strains of Mycobacterium tuberculosis (Mtb) that are resistant to …

Curcumin is a natural product with several thousand years of heritage. Its traditional Asian
application to human ailments has been subjected in recent decades to worldwide …

The elevation of oxidative stress preferentially in cancer cells by inhibiting thioredoxin
reductase (TrxR) and/or enhancing reactive oxygen species (ROS) production has emerged …

Curcumin has a variety of anticancer properties, but low bioavailability prevents its use in
chemotherapeutic applications. To address this problem, we tested the efficacy of the …

Curcumin, a pure compound extracted from the flowering plant, turmeric (Curcuma longa.
Zingiberaceae), is a common dietary ingredient found in curry powder. It has been studied …