Low back pain (LBP) is a common disease that imposes a huge social and economic
burden on people. Intervertebral disc (IVD) degeneration (IVDD) is often considered to be …

The communication of cells with their surroundings is mostly encoded in the epitopes of
structural and signalling proteins present in the extracellular matrix (ECM). These peptide …

Effective therapeutic approaches to overcome the heterogeneous pro-inflammatory and
inhibitory extracellular matrix (ECM) microenvironment are urgently needed to achieve …

Collagen, classically derived from animal tissue, is an all-important protein material widely
used in biomedical materials, cosmetics, fodder, food, etc. The production of recombinant …

Low back pain (LBP), caused by intervertebral disc (IVD) degeneration, is a major
contributor to global disability. In its healthy state, the IVD is a tough and well-hydrated …

The intervertebral disc (IVD) is the fibrocartilaginous joint located between each vertebral
body that confers flexibility and weight bearing capabilities to the spine. The IVD plays an …

Collagen, the most abundant component of natural ECM, has attracted interest of scientific
communities to replicate its multihierarchical self-assembling structure. Recent …

Degenerated intervertebral discs (IVDs) were treated with autologous adipose-derived stem
cells (ASC) loaded into an injectable collagen scaffold in a sheep model to investigate the …

Synthetic bioactive hydrogels have been widely recognized as key elements of emerging
strategies for tissue engineering. The complex hierarchical structure and chemical …

The extracellular matrix (ECM) is a protein-and-carbohydrate meshwork that supports a
variety of biological structures and processes, from tissue development and elasticity to the …