Aging is a modifiable risk factor for most chronic diseases and an inevitable process in
humans. The development of pharmacological interventions aimed at delaying or preventing …

The use of deuterium oxide (D2O) has greatly expanded the scope of what is possible for
the measurement of protein synthesis. The greatest asset of D2O labeling is that it facilitates …

In genetically heterogeneous mice produced by the CByB6F1 x C3D2F1 cross, the “non‐
feminizing” estrogen, 17‐α‐estradiol (17aE2), extended median male lifespan by 19%(p< …

The skeletal muscle research field generally accepts that nuclei in skeletal muscle fibers (ie,
myonuclei) are post-mitotic and unable to proliferate. Because our deuterium oxide (D2O) …

Abstract Calorie restriction (CR)(25–40%) is the most commonly studied strategy for
curtailing age-related disease and has also been found to extend reproductive lifespan in …

Metabolic dysfunction underlies several chronic diseases, many of which are exacerbated
by obesity. Dietary interventions can reverse metabolic declines and slow aging, although …

Estrogen receptor alpha (ERα) plays a crucial role in reproductive function in both sexes. It
also mediates cellular responses to estrogens in multiple nonreproductive organ systems …

Aging is the greatest risk factor for most chronic diseases. The somatotropic axis is one of
the most conserved biological pathways that regulates aging across species. 17α-Estradiol …

The rationale for the use of metformin as a treatment to slow aging was largely based on
data collected from metabolically unhealthy individuals. For healthspan extension metformin …

Loss of protein homeostasis is a hallmark of the aging process. We and others have
previously shown that maintenance of proteostasis is a shared characteristic of slowed …