[HTML][HTML] Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells
M Cnop, S Toivonen, M Igoillo-Esteve, P Salpea - Molecular metabolism, 2017 - Elsevier
Background Pancreatic β cell dysfunction and death are central in the pathogenesis of most
if not all forms of diabetes. Understanding the molecular mechanisms underlying β cell …
if not all forms of diabetes. Understanding the molecular mechanisms underlying β cell …
The molecular functions of hepatocyte nuclear factors–In and beyond the liver
The hepatocyte nuclear factors (HNFs) namely HNF1α/β, FOXA1/2/3, HNF4α/γ and
ONECUT1/2 are expressed in a variety of tissues and organs, including the liver, pancreas …
ONECUT1/2 are expressed in a variety of tissues and organs, including the liver, pancreas …
A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies
Fragile X syndrome (FXS) is caused by the loss of fragile X mental retardation protein
(FMRP), an RNA-binding protein that can regulate the translation of specific mRNAs. In this …
(FMRP), an RNA-binding protein that can regulate the translation of specific mRNAs. In this …
Towards a better understanding of diabetes mellitus using organoid models
BS Beydag-Tasöz, S Yennek… - Nature Reviews …, 2023 - nature.com
Our understanding of diabetes mellitus has benefited from a combination of clinical
investigations and work in model organisms and cell lines. Organoid models for a wide …
investigations and work in model organisms and cell lines. Organoid models for a wide …
The human islet: mini-organ with mega-impact
JT Walker, DC Saunders, M Brissova… - Endocrine …, 2021 - academic.oup.com
This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …
development, function, and dysfunction. After providing a historical timeline of key …
Modelling the endocrine pancreas in health and disease
Diabetes mellitus is a multifactorial disease affecting increasing numbers of patients
worldwide. Progression to insulin-dependent diabetes mellitus is characterized by the loss …
worldwide. Progression to insulin-dependent diabetes mellitus is characterized by the loss …
Towards a functional cure for diabetes using stem cell-derived beta cells: are we there yet?
S Bourgeois, T Sawatani, A Van Mulders, N De Leu… - Cells, 2021 - mdpi.com
Diabetes mellitus is a pandemic metabolic disorder that results from either the autoimmune
destruction or the dysfunction of insulin-producing pancreatic beta cells. A promising cure is …
destruction or the dysfunction of insulin-producing pancreatic beta cells. A promising cure is …
[HTML][HTML] Point mutations in the PDX1 transactivation domain impair human β-cell development and function
Objective Hundreds of missense mutations in the coding region of PDX1 exist; however, if
these mutations predispose to diabetes mellitus is unknown. Methods In this study, we …
these mutations predispose to diabetes mellitus is unknown. Methods In this study, we …
Maturity onset diabetes of the young—new approaches for disease modelling
D Skoczek, J Dulak… - International Journal of …, 2021 - mdpi.com
Maturity-onset diabetes of the young (MODY) is a genetically heterogeneous group of
monogenic endocrine disorders that is characterised by autosomal dominant inheritance …
monogenic endocrine disorders that is characterised by autosomal dominant inheritance …
[HTML][HTML] Stem-cell based organ-on-a-chip models for diabetes research
Diabetes mellitus (DM) ranks among the severest global health concerns of the 21st century.
It encompasses a group of chronic disorders characterized by a dysregulated glucose …
It encompasses a group of chronic disorders characterized by a dysregulated glucose …