KRAS G12C mutations in NSCLC: from target to resistance
Simple Summary A better understanding of the role of KRAS and its different mutations has
led to the development of specific small-molecule inhibitors able to target KRAS G12C, an …
led to the development of specific small-molecule inhibitors able to target KRAS G12C, an …
Overcoming Immune Checkpoint Therapy Resistance with SHP2 Inhibition in Cancer and Immune Cells: A Review of the Literature and Novel Combinatorial …
Simple Summary This is a thorough literature review of SHP2 inhibition, its application in
cancer therapy and current uses as an immune modulator. The aberrant activation of SHP2 …
cancer therapy and current uses as an immune modulator. The aberrant activation of SHP2 …
An allosteric interaction controls the activation mechanism of SHP2 tyrosine phosphatase
M Anselmi, JS Hub - Scientific reports, 2020 - nature.com
SHP2 is a protein tyrosine phosphatase (PTP) involved in multiple signaling pathways.
Mutations of SHP2 can result in Noonan syndrome or pediatric malignancies. Inhibition of …
Mutations of SHP2 can result in Noonan syndrome or pediatric malignancies. Inhibition of …
SHP-2-Mediated upregulation of ZEB1 is important for PDGF-B-Induced cell proliferation and metastatic phenotype in triple negative breast cancer
L Zhang, C Yuan, J Peng, L Zhou, Y Jiang, Y Lin… - Frontiers in …, 2020 - frontiersin.org
Background: Triple negative breast cancer (TNBC), a fatal malignant tumor, is characterized
by a lack of estrogen and progesterone hormone receptors and overexpression of HER2 …
by a lack of estrogen and progesterone hormone receptors and overexpression of HER2 …
SHP2 is involved in the occurrence, development and prognosis of cancer
S Li, J Qu, X Wang, Q Zou, C Li - Oncology Letters, 2023 - spandidos-publications.com
Src homology‑2 domain‑containing protein tyrosine phosphatase (SHP2), encoded by
protein tyrosine phosphatase non‑receptor type 11 (PTPN11), is widely expressed in several …
protein tyrosine phosphatase non‑receptor type 11 (PTPN11), is widely expressed in several …
Ligand-induced conformational transitions in the activation mechanism of SHP2 tyrosine phosphatase
M Anselmi, JS Hub - bioRxiv, 2020 - biorxiv.org
ABSTRACT SHP2 is a protein tyrosine phosphatase with a key role in multiple signaling
pathways, including the RAS-MAPK cascade. Germline mutations in PTPN11, the gene …
pathways, including the RAS-MAPK cascade. Germline mutations in PTPN11, the gene …