In-silico functional and structural annotation of hypothetical protein from Klebsiella pneumonia: A potential drug target

V Singh, P Dhankhar, V Dalal, S Tomar… - Journal of Molecular …, 2022 - Elsevier
Klebsiella pneumonia is known to cause several nosocomial infections in
immunocompromised patients. It has developed resistance against a broad range of …

Differential analysis of Orientia tsutsugamushi genomes for therapeutic target identification and possible intervention through natural product inhibitor screening

Z Basharat, U Akhtar, K Khan, G Alotaibi, K Jalal… - Computers in Biology …, 2022 - Elsevier
Orientia tsutsugamushi (Ott) is a causative agent of scrub typhus, and one of the emerging
pathogens that could affect a large human population. It is one of the misdiagnosed and …

Domain‐wise differentiation of Mycobacterium tuberculosis H37Rv hypothetical proteins: A roadmap to discover bacterial survival potentials

MA Beg, II Hejazi, SC Thakur… - … and applied biochemistry, 2022 - Wiley Online Library
Proteomic information revealed approximately 3,923 proteins in Mycobacterium tuberculosis
H37Rv genome of which around∼ 25% of proteins are hypothetical proteins (HPs). The …

Characterization of sodium carboxymethyl cellulose/calcium alginate scaffold loaded with curcumin in skin tissue engineering

M Rezaei, N Hassanzadeh Nemati… - Journal of Applied …, 2022 - Wiley Online Library
Applying biological macromolecule like curcumin (CUC) has gained considerable attention
for the anti‐inflammatory, antioxidant, antimicrobial and antitumor properties. Therefore, this …

Dominant B cell-T cell epitopes instigated robust immune response in-silico against Scrub Typhus

S Agarwal, HH Chandpa, S Naskar, CL Meena… - Vaccine, 2024 - Elsevier
Scrub typhus, a potentially life-threatening infectious disease, is attributed to bacteria
Orientia tsutsugamushi (O. tsutsugamushi). The transmission of this illness to humans …

Targeting Essential Hypothetical Proteins of Pseudomonas aeruginosa PAO1 for Mining of Novel Therapeutics: An In Silico Approach

A Rahman, MT Sarker, MA Islam… - BioMed Research …, 2023 - Wiley Online Library
As an omnipresent opportunistic bacterium, Pseudomonas aeruginosa PAO1 is responsible
for acute and chronic infection in immunocompromised individuals. Currently, this bacterium …

In silico prediction of CD8+ and CD4+ T cell epitopes in Leishmania major proteome: Using immunoinformatics

M Kashif, M Waseem, N Subbarao - Journal of Molecular Graphics and …, 2024 - Elsevier
The leishmaniases are NDTs (neglected tropical diseases) that affect people all over the
world. They are brought on by protozoans from the genus Leishmania and disseminated by …

Oman higher education institutions dealing with artificial intelligence

IAH Ayed - 2022 - search.proquest.com
Investigação abundante em inteligência artificial (IA) e nos avanços da tecnologia tem-se
focado na melhoria da capacidade de tomada de decisão e correspondentes transações …

An educational bioinformatics project to improve genome annotation

Z Amatore, S Gunn, LK Harris - Frontiers in Microbiology, 2020 - frontiersin.org
Scientific advancement is hindered without proper genome annotation because biologists
lack a complete understanding of cellular protein functions. In bacterial cells, hypothetical …

Exploration of Streptococcus core genome to reveal druggable targets and novel therapeutics against S. pneumoniae

ZM Chowdhury, A Bhattacharjee, I Ahammad… - Plos one, 2022 - journals.plos.org
Streptococcus pneumoniae (S. pneumoniae), the major etiological agent of community-
acquired pneumonia (CAP) contributes significantly to the global burden of infectious …