Venoms as a platform for human drugs: translating toxins into therapeutics

GF King - Expert opinion on biological therapy, 2011 - Taylor & Francis
Introduction: An extraordinarily diverse range of animals have evolved venoms for predation,
defence, or competitor deterrence. The major components of most venoms are peptides and …

The toxicogenomic multiverse: convergent recruitment of proteins into animal venoms

BG Fry, K Roelants, DE Champagne… - Annual review of …, 2009 - annualreviews.org
Throughout evolution, numerous proteins have been convergently recruited into the venoms
of various animals, including centipedes, cephalopods, cone snails, fish, insects (several …

The evolution, function and mechanisms of action for plant defensins

K Parisi, TMA Shafee, P Quimbar… - Seminars in cell & …, 2019 - Elsevier
Plant defensins are an extensive family of small cysteine rich proteins characterised by a
conserved cysteine stabilised alpha beta protein fold which resembles the structure of insect …

Scorpion venom components that affect ion-channels function

V Quintero-Hernández, JM Jiménez-Vargas… - Toxicon, 2013 - Elsevier
The number and types of venom components that affect ion-channel function are reviewed.
These are the most important venom components responsible for human intoxication …

Convergent evolution of defensin sequence, structure and function

TMA Shafee, FT Lay, TK Phan, MA Anderson… - Cellular and Molecular …, 2017 - Springer
Defensins are a well-characterised group of small, disulphide-rich, cationic peptides that are
produced by essentially all eukaryotes and are highly diverse in their sequences and …

Scorpion venom and the inflammatory response

VL Petricevich - Mediators of inflammation, 2010 - Wiley Online Library
Scorpion venoms consist of a complex of several toxins that exhibit a wide range of
biological properties and actions, as well as chemical compositions, toxicity, and …

Overview of scorpion toxins specific for Na+ channels and related peptides: biodiversity, structure–function relationships and evolution

RCR de la Vega, LD Possani - Toxicon, 2005 - Elsevier
Scorpion venoms contain a large number of bioactive components. Several of the long-
chain peptides were shown to be responsible for neurotoxic effects, due to their ability to …

Snake Venomics of the Central American Rattlesnake Crotalus simus and the South American Crotalus durissus Complex Points to Neurotoxicity as an Adaptive Paedomorphic …

JJ Calvete, L Sanz, P Cid, P de la Torre… - Journal of proteome …, 2010 - ACS Publications
We report a comparative venomic and antivenomic characterization of the venoms of
newborn and adult specimens of the Central American rattlesnake, Crotalus simus, and of …

Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment

SIV Judge, CT Bever Jr - Pharmacology & therapeutics, 2006 - Elsevier
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by demyelination, with a relative sparing of axons. In MS patients, many …

Defensin-like ZmES4 mediates pollen tube burst in maize via opening of the potassium channel KZM1

S Amien, I Kliwer, ML Márton, T Debener, D Geiger… - PLoS …, 2010 - journals.plos.org
In contrast to animals and lower plant species, sperm cells of flowering plants are non-motile
and are transported to the female gametes via the pollen tube, ie the male gametophyte …