This evidence-based review addresses the question of whether testing for UGT1A1
mutations in patients with metastatic colorectal cancer treated with irinotecan leads to …

Pyrosequencing is a real-time bioluminometric technique for determination of nucleic acid
sequence. Here, we review recent advances and discuss new applications of this technique …

The incidence of severe neonatal hyperbilirubinemia is higher in Asians than in whites. A
case-control study was designed to investigate the effects of eight known risk factors [breast …

Purpose: We wanted to assess polymorphisms in the uridine diphosphoglucuronosyl
transferase 1A1 (UGT 1A1) gene: the TATA box polymorphism and UGT 1A1 G71R and …

Purpose A comprehensive haplotype analysis of UGT1A1 in the Japanese population was
conducted, and the effects of these haplotypes were investigated with respect to UGT1A1 …

Interindividual pharmacokinetic variability of the anticancer agent irinotecan is high. Life‐
threatening diarrhea is observed in up to 25% of patients receiving irinotecan and has been …

The sequencing of the human genome has allowed the identification of thousands of gene
polymorphisms, most often single nucleotide polymorphims (SNP), which may play an …

Variants within the human UGT1A1 gene are associated with irinotecan induced severely
adverse reactions and hyperbilirubinemia. Intra-ethnic differences in the genetic variation …

Background: Unopposed estrogen replacement therapy is associated with increased risk of
endometrial cancer. To investigate the mechanism of this association, we evaluated whether …

Purpose The primary aim of this research was to investigate the association between uridine
diphosphate glucuronosyltransferase (UGT) 1A1 gene polymorphisms and the toxicities of …