Immune responses must be tightly regulated to ensure both optimal protective immunity and
tolerance. Costimulatory pathways within the B7: CD28 family provide essential signals for …

Over the past decade, V-domain immunoglobulin suppressor of T-cell activation (VISTA) has
been established as a negative immune checkpoint molecule. Since the role of VISTA in …

Studying the tumor microenvironment and surrounding lymph nodes is the main focus of
current immunological research on soft tissue sarcomas (STS). However, due to the …

Cancer immunotherapy, leveraging antibodies, excels in targeting efficacy but faces hurdles
in tissue penetration, oral delivery, and prolonged half-life, with costly production and risk of …

Synovial sarcoma is an aggressive soft-tissue cancer that shows limited responses to
current immunotherapeutic approaches using immune checkpoint blockade or adoptive cell …

In recent years, significant advancements have been achieved in the development of
multiplex imaging methodologies for immunophenotyping, enabling a comprehensive …

Cancers evade T-cell immunity by several mechanisms such as secretion of anti-
inflammatory cytokines, downregulation of antigen presentation machinery, upregulation of …